Longevity / Anti-Aging Protocol
Goal
Hit multiple Hallmarks of Aging at once for healthspan — applied age-/biomarker-gated, not maximally.
Provenance & framing
Research/educational only. Lifespan claims are mostly preclinical; GH/IGF-1 has a U-shaped mortality curve. Layer peptides onto the proven behavioral base only when labs warrant.
Why it synergises (three layers)
- Peptides — different hallmarks each: FOXO4-DRI (cellular senescence, Senolysis), Epithalon (telomeres/epigenetics/circadian, Telomerase Activation), Thymosin Alpha-1 (immunosenescence, Thymic Immune Modulation), MOTS-C/SS-31 (mitochondrial), low-dose Semaglutide (multiple, ~−12% all-cause mortality).
- Supplements: NAD/NMN (complex I), CoQ10 (complex III), Glycine (phase-2 detox/sleep).
- Behaviors (the proven base): Zone 2 Cardio + Resistance Training (muscle = longevity), Fasting (AMPK/autophagy), Sauna, Sleep Hygiene, Morning Sunlight.
Timing & intake
- Peptides cycled per their own protocols and started when biomarkers show the relevant decline (e.g. CD4:CD8 <1 → thymosin α1; low cardiolipin/age 50+ → SS-31). Behaviors are daily/ongoing.
Cautions
[warning]Don’t max GH/IGF-1; screen for cancer (angiogenic/senolytic agents); most peptide longevity data is preclinical — behaviors carry the proven weight.
Evidence backing
- Longevity Top-5; per-peptide papers in each note.
Monitoring
- Biological-age/biomarker panels, CD4:CD8, fasting glucose/A1C, IGF-1, lipids.