Ipamorelin: The Selective GH Secretagogue

Research on the cleanest growth hormone releasing peptide

Source: https://indexalabs.com/blog/ipamorelin-selective-gh-secretagogue Abstract: Ipamorelin is the most selective GH secretagogue available, stimulating growth hormone release without significantly affecting cortisol, prolactin, or other hormones. This guide covers its unique selectivity and research applications.

1. Introduction

Ipamorelin is a pentapeptide growth hormone secretagogue that selectively stimulates GH release through the ghrelin/GHS receptor. Unlike older GHRPs like GHRP-6, Ipamorelin does not significantly increase cortisol, ACTH, prolactin, or appetite, making it the “cleanest” GH secretagogue.

2. Mechanisms of Action

2.1 Selective GHS-R Activation Ipamorelin activates the ghrelin receptor in a highly selective manner.

2.2 Dose-Dependent GH Release GH release increases proportionally with dose up to saturation.

2.3 No Cortisol Increase Unlike GHRP-2 and GHRP-6, Ipamorelin does not stimulate cortisol release.

2.4 Minimal Prolactin Effect No significant prolactin elevation at therapeutic doses.

3. Selectivity Advantages

3.1 Clean GH Pulse Pure GH release without hormonal side effects.

3.2 No Appetite Stimulation Unlike GHRP-6, Ipamorelin does not increase hunger.

3.3 No Desensitization Research suggests less receptor desensitization than other GHRPs.

3.4 Combination Friendly Excellent for combining with GHRH analogs like CJC-1295.

4. Research Protocols

4.1 Available Sizes Ipamorelin is available in 10mg vials and in combination with CJC-1295 (5mg/5mg).

4.2 Timing Typically studied with administration at bedtime or around training.

4.3 Synergistic Combinations Most commonly combined with CJC-1295 (no DAC) for amplified GH release.