Mechanisms of action of glucagon-like peptide-1

Key finding

Maps the cell-type-specific GLP-1 receptor circuits underlying glycemic control, appetite suppression, gastric emptying and the cardiovascular/anti-inflammatory actions of GLP-1 receptor agonists.

Method / model

Authoritative mechanistic review (Cell Metab 2018;27:740-756).

Relevance

Core reference for the GLP-1 Agonism mechanism and Semaglutide/Tirzepatide.

Drucker, D.J. (2018). Mechanisms of action of glucagon-like peptide-1. Cell Metabolism, 27(4), 740-756.