Ipamorelin, the first selective growth hormone secretagogue

Key finding

Characterises ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) as the first GH secretagogue to release GH with potency comparable to GHRP-6 but WITHOUT elevating ACTH or cortisol — establishing its selectivity advantage.

Method / model

In-vitro pituitary cell and in-vivo rat/swine studies.

Relevance

Selectivity basis for Ipamorelin preference in GH-axis stacks.

Raun, K. et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552-561.