What it is

Peptides acting on it

Evidence

  • [educational] GHK-Cu promotes angiogenesis via VEGF/FGF-2 upregulation (supplying skin/hair/tissue with nutrients for repair) — a shared mechanism with BPC-157, and a reason for the same cancer-caution framing. — GHK-Cu deep dive

  • [educational] TB4 promotes angiogenesis via actin-driven endothelial migration — less potent than BPC-157’s NO/VEGF route, but complementary (why the two are combined for major injuries); also a shared cancer-caution mechanism. — TB500 deep dive

  • [literature] First human RCTs of both angiogenic repair peptides registered (2026): BPC-157 SubQ for acute hamstring strain (SOURCE-bpc157-hamstring-rct-nct07437547) and a TB-500 (TB4 17–23) Phase 1/2 in stable ASCVD (SOURCE-tb500-ascvd-rct-nct07487363) — both recruiting, no results yet.