[anecdote] The ‘cleanest’ GH secretagogue — most receptor-specific but weakest pulse; users lean out and sleep better with no real side effects. — Koniver 00:51
[anecdote] Mechanistically a type-2 ghrelin-mimetic: raises GH directly and by suppressing somatostatin (releases the brake); raises ghrelin → hunger/anxiety; deepens sleep (possible REM cost). — Huberman 00:54–00:55
[anecdote-bb] Quant. estimate: ~125 mcg ipamorelin → ~0.5–0.7 IU GH; saturation ~125–150 mcg; favored over GHRP-2/6 (no prolactin/cortisol); poor cost-per-IU vs pharma GH for muscle. — Anabolic Roundtable ~00:22–00:26
[anecdote-bb] Community/enhancement dosing 150–300 mcg SubQ; favored GHRP for lacking prolactin/cortisol effects. — Vigorous Steve
[educational] Best GHRP by selectivity (no ACTH/cortisol even at high doses in swine; mild appetite); GH potency ≈ GHRP-6. Use only with a GHRH — GHRP monotherapy fails long-term (GHSR desensitizes + somatostatin rises). Combined GHRH+GHRP shows a 66% synergistic GH increase; pulsatile ipamorelin synergizes better than continuous MK-677. — GH selection guide
Physician protocols
[protocol]100 mcg ceiling, pre-sleep, no carbohydrates within ~45 min. [warning] Rare anaphylaxis reported when pushed to 200–400 mcg; do not use flushing/tingling as an efficacy signal. — Koniver 00:49–00:53
[protocol]Only use with a GHRH (alone → rapid desensitization). Start 100 mcg, cautious up to 200 mcg with monitoring; inject together with the GHRH at night. Most selective GHRP → least prolactin/cortisol/thyroid effect. — GH admin guide
Practical notes
[warning] Stacked with tesamorelin it amplifies GH/IGF-1 but worsens insulin resistance; ghrelin-agonism drives hunger. — Bakri 02:13–02:14