Fasting (Time-Restricted Eating)

What it is

• Caloric restriction windows — from daily time-restricted eating to longer fasts.

How it works

• Low insulin/glucose → AMPK activation, raised endogenous GH (somatostatin low), increased fat oxidation, autophagy, and a hormetic adaptation that MOTS-C partly mimics (‘exercise/fasting in a vial’).

Goal relevance

• Fat loss + metabolic/longevity; explains why pre-sleep and morning peptide dosing is timed away from food (food blunts the GH response).

How to do it

• e.g. a daily eating window; avoid eating ~2–4 h before a pre-sleep GH peptide.

Cautions

• Can erode lean mass / training performance if too aggressive; not for everyone.