Somatostatin

Definition

• [educational] The hormone (a.k.a. GHIH) that inhibits growth-hormone release; rises with eating and with high IGF-1.

Why it matters

• [educational] It’s the brake on the GH axis — lowest at night (enabling the big pulse) and raised by food/feedback. Why GH peptides are dosed at night, fasted, and why GHRH Analog/Ghrelin-GHRP Agonism agents work better when somatostatin is low.