What it is

Peptides acting on it

Evidence

  • [educational] Primary hypogonadism = failing testes → high LH/FSH + low T (HCG/Clomid won’t help → TRT). Secondary = under-signalling → low/normal LH/FSH + low T (where Clomid/HCG work). Levers by site: Kisspeptin-10 (GnRH) → Clomid/enclomiphene (hypothalamic estrogen-receptor block) → HCG (testicular LH receptor). — testosterone guide