[anecdote] Thought to regenerate pinealocytes; reported to roughly double REM sleep (tracked, Huberman n=1), with the effect persisting on non-dosing nights; Koniver reports the same pattern across patients; no negative side effects observed. — Koniver 01:24–01:30
[anecdote] Tripeptide EDR; despite the name it derives from a cortex extract (cortexin), not the pineal. Epigenetic modifier (binds DNA groove); modulates PPARα/γ, SOD, IRIS → daytime alertness, HIIT performance, and more REM, with benefits persisting off-dose. — Bakri 01:08–01:18
Physician protocols
[protocol] Injectable, combined with glycine (oral glycine 3–5 g, up to 10 g, at bedtime). Can be pulsed intermittently rather than nightly. — Koniver 01:30–01:35
[protocol] Oral ~0.5–3 mg (Russian Khavinson product ~200 mcg); some inject (systemic via PEPT transporters). Morning for cognition/performance; high evening doses sedate. — Bakri 01:13–01:16
Practical notes
[warning] Can lower blood sugar / A1C (PPAR activation — caution if hypoglycemia-prone) and cause vivid dreams/nightmares. — Bakri 01:17