[anecdote-bb] Ghrelin (stomach, on hunger) enhances GHRH’s effect and drives a GH pulse — but the effect collapses when somatostatin is high (e.g. after eating). Arginine 5–10 g (with ornithine/lysine) blunts somatostatin, partly rescuing a GHRP dose taken on a full stomach. Hunger is the expected side effect. — Vigorous Steve
[educational] GHRP receptor is especially prone to desensitization → use a GHRP (e.g. ipamorelin) with a GHRH for synergy, not alone; ipamorelin’s selectivity minimises prolactin/cortisol off-effects. — GH admin guide