Hallmarks of Aging

Definition

  • [educational] The ~12 root-cause processes of aging (genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, cellular senescence, inflammation, etc.).

Why it matters

  • [educational] The lens for ranking longevity peptides: FOXO4-DRI → senescence, Epithalon → telomeres/epigenetics, MOTS-C/SS-31 → mitochondria, GLP-1s → multiple. The more hallmarks a peptide targets, the stronger its longevity rationale.