[anecdote-bb] GH is secreted in pulses (~3–5 large + 5–7 small/24 h); biggest pulse in early sleep, melatonin-augmented. With age pulse frequency holds but amplitude falls (~150→25 mcg/kg/day puberty→55, ~85% drop). Secretagogues are rate-limited by the pituitary → modest GH, especially in older users. — Vigorous Steve
[educational] Practical optimisation: dose at night right before sleep (align with the natural deep-sleep pulse, lowest somatostatin), 5 days on / 2 off, ~3–4 months on / 1 month off to limit accumulated desensitization. Both too-low and too-high GH/IGF-1 track higher mortality — augment, don’t override. — GH admin guide
[educational] GH is pulsatile (93% in pulses q2–3h, 7% basal; largest post-sleep-onset; males 70–85% nocturnal). Aging lowers pulse amplitude, not frequency/basal — so raising basal/trough (CJC-DAC ~7.5×, MK-677 ~3.5×) is non-physiologic; short-acting GHRH+GHRP raise amplitude and return to baseline (where AMPK/sirtuin repair pathways switch on). — GH selection guide