DPP-4

Definition

• [educational] Dipeptidyl peptidase-4 — the enzyme that rapidly degrades GLP-1 (native half-life ~2 min) and other peptides.

Why it matters

• [educational] GLP-1 drugs are engineered for DPP-4 resistance (the basis of Semaglutide’s long half-life); DPP-4 inhibitors are sometimes misused to extend injectable GH-peptide half-life (thin evidence — see Vigorous Steve transcript).