Fertility / Hormone-Restoration Protocol

Goal

Raise endogenous testosterone while preserving/restoring fertility — and reboot the axis after TRT/steroids.

Provenance & framing

Research/educational only; with a physician + labs. For secondary hypogonadism (low/normal LH/FSH); won’t fix primary (failing testes).

Why it synergises (three layers)

• Compounds/peptides by axis level: Kisspeptin-10 (most upstream → GnRH), Clomiphene/Enclomiphene (hypothalamic estrogen-receptor block → ↑LH and FSH → testosterone and sperm), HCG (testicular LH receptor → testosterone, preserves testicular function). (See Clomiphene/Enclomiphene compounds.)
• Behaviors: Sleep Hygiene, Resistance Training, weight/metabolic management (Fasting) — fixing the root causes of low T first.

Timing & intake

• Clomid 25 mg EOD → 50; enclomiphene 12.5–25 mg; HCG 500→1,000 IU 2×/wk; choose by age (<45 favors Clomid/HCG), fertility goal (Clomid raises FSH/sperm), estrogen/prolactin.

Cautions

• [warning] Primary hypogonadism won’t respond; Clomid can raise estrogen (zuclomiphene); not used alongside TRT (which suppresses the axis).

Evidence backing

• testosterone guide (HPG framework, Clomid/HCG/enclomiphene).

Monitoring

• LH/FSH, total/free testosterone, estradiol, semen analysis if fertility is the goal.