AMPK

Definition

• [educational] AMP-activated protein kinase — the cell’s master energy sensor/regulator, activated when energy is low.

Why it matters

• [educational] MOTS-C (and exercise, fasting, metformin) activate AMPK → SIRT1/PGC-1α → mito biogenesis, fat/glucose handling, ↓inflammation; the catabolic/repair counterweight to mTOR growth signaling.