Peptide promotes overcoming of the division limit in human somatic cell

Key finding

Epithalon (Ala-Glu-Asp-Gly) induced telomerase activity and ~2.4x telomere elongation in human somatic (fetal fibroblast) cells, extending divisions by ~42.5% — evidence of overcoming the Hayflick limit in vitro.

Method / model

Human fetal fibroblast cell culture.

Relevance

Core in-vitro support for Epithalon telomere claims (note: human cell line, not in-vivo).

Khavinson, V.K., et al. (2003). Peptide promotes overcoming of the division limit in human somatic cell. Bulletin of Experimental Biology and Medicine, 135(6), 612-614.