First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

Key finding

SS-31 (elamipretide) selectively concentrates in the inner mitochondrial membrane and binds cardiolipin, protecting cristae architecture and restoring oxidative phosphorylation under stress — defining the first-in-class cardiolipin-targeted mitoprotective mechanism.

Method / model

Review of the SS-peptide pharmacology and cardiolipin-binding data.

Relevance

Foundational mechanism reference for SS-31 and Mitochondrial Bioenergetics.

Szeto, H.H. (2014). First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. British Journal of Pharmacology, 171(8), 2029-2050.