Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

Key finding

The melanocortin-derived tripeptide KPV showed significant anti-inflammatory activity in two murine colitis models (DSS and CD45RBhi transfer), with effects at least partly independent of MC1R signalling.

Method / model

Two murine IBD models.

Relevance

Mechanistic basis for KPV anti-inflammatory / gut claims.

Kannengiesser, K., et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases, 14(3), 324-331.