[anecdote] Sits upstream of kisspeptin → GnRH → LH/FSH → testosterone/estrogen; triggers puberty; synthetic form prescribed for hypothalamic amenorrhea; taken for vitality/libido (a ‘wild card’ — recently discovered, pleiotropic). Antagonists treat menopausal vasomotor symptoms. — Huberman 01:17–01:21
[educational] Sits at the top of the HPG testosterone levers: Kisspeptin (→GnRH) is most upstream, vs Clomid/enclomiphene (hypothalamus → ↑LH/FSH) and HCG (testes → mimics LH); TRT bypasses and suppresses the whole axis. — testosterone guide