[educational] GHRH = 44-aa hypothalamic peptide → pituitary GH. Analogs: tesamorelin (44 aa + trans-hexenoic acid), sermorelin (first 29 aa), CJC-1295 (29 aa + 4 changes ± DAC). GHRH desensitizes far less than GHRPs and upregulates GHSR synthesis (enabling GHRH+GHRP synergy) → it’s the base of any stack. — GH selection guide
Peptides acting on it
Evidence
[anecdote-bb] GHRH release is pulsatile, rising with low blood glucose and during sleep; inhibited by circulating IGF-1 and GABAergic neurons. GHRH-analog secretagogues exploit this rhythm. — Vigorous Steve
[educational] Night dosing yields a bigger GH spike and less receptor desensitization than daytime (lower nighttime somatostatin); GH peaks ~30–45 min after SubQ. Oral GHRH ≈ 0% bioavailable; the pituitary sits outside the blood-brain barrier, so systemic (SubQ) delivery is the goal. — GH admin guide