The promoting effect of BPC 157 on tendon healing

Key finding

BPC-157 promoted tendon-fibroblast outgrowth, survival under stress and migration via the FAK-paxillin pathway, and increased growth-hormone-receptor expression in tendon fibroblasts — a mechanism for accelerated tendon healing.

Method / model

Rat Achilles tendon explant + fibroblast culture (in vitro/ex vivo).

Relevance

Key tendon-healing mechanism for BPC-157.

Chang, C.H. et al. (2011). The promoting effect of BPC 157 on tendon healing. Journal of Applied Physiology, 110(3), 774-780.