The GH/IGF-1 axis in ageing and longevity

Key finding

GH/IGF-1 secretion declines with age; paradoxically, mutations that LOWER GH/IGF-1 tone are associated with extended longevity in mice — framing the trade-off between GH-driven anabolism and lifespan.

Method / model

Review of GH/IGF-1 axis genetics and aging.

Relevance

Key caveat reference balancing GH-secretagogue stacks against longevity goals.

Junnila, R.K. et al. (2013). The GH/IGF-1 axis in ageing and longevity. Nature Reviews Endocrinology, 9(6), 366-376.