Brain-gut Axis and Pentadecapeptide BPC 157

Key finding

Comprehensive review establishing BPC-157 as a stable gastric pentadecapeptide that acts along the gut-brain axis — cytoprotective/angiogenic in the GI tract and neuroprotective centrally (stroke, TBI, nerve healing), with no toxicity reported in animal models.

Method / model

Narrative review of the animal BPC-157 literature.

Relevance

Anchor mechanism reference for BPC-157 across gut, vascular and neuro effects.

Sikiric, P., et al. (2018). Brain-gut Axis and Pentadecapeptide BPC 157. Current Neuropharmacology, 16(3), 339-345.