PT-141

Overview

Mechanisms

Evidence

Anecdotes

• [anecdote] Melanocortin agonist; FDA-approved (Vyleesi) for female hypoactive sexual desire; neurogenic ED mechanism (not blood-flow based). — Koniver 02:07–02:08

• [anecdote] Melanocortin agonist (Vyleesi); FDA-approved for premenopausal hypoactive sexual desire in women, off-label in men. — Huberman 01:15–01:16

Physician protocols

• [protocol] Narrow therapeutic window — over-dosing causes nausea quickly. — Koniver 02:09

Practical notes

• [warning] Side effects: nausea (gut MSH receptors), skin flushing, raised blood pressure, pigmentation; melanoma caution. — Huberman 01:15–01:17