SS-31 (Elamipretide): Mitochondrial Protector

Research on the cardiolipin-targeting peptide for cellular energy optimization

Source: https://indexalabs.com/blog/ss-31-elamipretide-mitochondrial-protection Abstract: SS-31 (Elamipretide) is a cell-permeable peptide that targets the inner mitochondrial membrane, specifically cardiolipin. It represents a unique approach to supporting mitochondrial function and cellular energy production.

1. Overview

SS-31 (D-Arg-Dmt-Lys-Phe-NH2), also known as Elamipretide or Bendavia, is a tetrapeptide that selectively concentrates in mitochondria and binds to cardiolipin, a phospholipid essential for electron transport chain function. This unique targeting makes it a powerful tool for mitochondrial research.

2. Mechanisms of Action

2.1 Cardiolipin Protection SS-31 stabilizes cardiolipin, preventing its oxidation and maintaining electron transport chain efficiency.

2.2 ROS Reduction By optimizing electron flow, SS-31 reduces mitochondrial reactive oxygen species production.

2.3 ATP Enhancement Improved electron transport leads to more efficient ATP production.

2.4 Mitochondrial Dynamics Research suggests effects on mitochondrial fusion/fission balance.

3. Clinical Research

3.1 Heart Failure Studies Phase 2 trials have examined SS-31 in primary mitochondrial myopathy and heart failure.

3.2 Ischemia-Reperfusion Research on protection during cardiac surgery and ischemic events.

3.3 Age-Related Decline Studies on mitochondrial dysfunction in aging.

3.4 Kidney Function Research on renal ischemia and function.

4. Research Protocols

4.1 Available Sizes SS-31 is available in 10mg vials.

4.2 Cell Permeability SS-31 rapidly enters cells without requiring transporters.

4.3 Dosing Considerations Research uses various routes including subcutaneous and intravenous administration.